2C-B Nexus Blue Bees, 2C-B (2,5-dimethoxy-4-bromophenethylamine) is a psychedelic drug of
the 2C family. It was rst synthesized by Alexander Shulgin in 1974. In Shulgin’s book PiHKAL, the
dosage range is listed as 12–24 mg. As a recreational drug, 2C-B is sold as a white powder
sometimes pressed in tablets or gel caps and is also referred to by a number of other names. The
drug is usually taken orally, but can also be snorted (insulated) or vaporized.
When orally consumed, 2C-B has a much longer delay before the onset of effects than when it is
insulated. Oral ingestion generally takes roughly 45–75 minutes for the effects to be felt, plateau
lasts 2–4 hours, and coming down lasts 1–2 hours. Rectal administration onset varies from 5–20
minutes. Insulated onset takes 1–10 minutes for effects to be felt. The duration can last from 4
to 12 hours depending on route of administration, dose, and other factors
With insulation, the effects are more abrupt and intense but have a signifcantly shorter duration,
while oral usage results in a milder, longer experience. When insulated, the onset happens very
rapidly, usually reaching the peak at about 20–40 minutes and plateauing for 2–3 hours. 2C-B Nexus Blue Bees is also considered one of the most painful drugs to insulate, with users
reporting intense nasal burning. The sudden intensity of the experience combined with the pain
can often start the experience with a negative imprint and nausea is also increased with
insulation, compounding the issue.